The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia.

Tibes, Raoul

The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia. [electronic resource] - Journal of hematology & oncology Oct 2015 - 114 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1756-8722

10.1186/s13045-015-0211-8 doi


Acute Disease
Aged
Aged, 80 and over
Anilides--pharmacology
Antimetabolites, Antineoplastic--pharmacology
Azacitidine--pharmacology
Biphenyl Compounds--pharmacology
Cell Line, Tumor
Cell Survival--drug effects
Chromosomes, Human, Pair 5--genetics
Chromosomes, Human, Pair 7--genetics
Drug Synergism
Female
HL-60 Cells
Hedgehog Proteins--genetics
High-Throughput Nucleotide Sequencing--methods
Humans
Leukemia, Myeloid--drug therapy
Male
Myelodysplastic Syndromes--drug therapy
Pyridines--pharmacology
RNA Interference
Signal Transduction--drug effects