The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation.

Lu, Dan

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. [electronic resource] - Nature immunology Dec 2015 - 1263-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2916

10.1038/ni.3278 doi


Animals
Cell Differentiation--immunology
Cells, Cultured
Colitis--chemically induced
Colitis, Ulcerative--genetics
Cytokines--immunology
DNA Methylation--immunology
Dextran Sulfate
Dual Specificity Phosphatase 2--deficiency
Gene Expression Regulation--immunology
HEK293 Cells
Humans
Immunoblotting
Inflammation Mediators--immunology
Mice, Inbred C57BL
Mice, Knockout
Phosphorylation--immunology
Protein Binding--immunology
Reverse Transcriptase Polymerase Chain Reaction
STAT3 Transcription Factor--immunology
Th17 Cells--immunology
Tyrosine--immunology