Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.
Benek, Ondrej
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease. [electronic resource] - ChemMedChem 06 2016 - 1264-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1860-7187
10.1002/cmdc.201500383 doi
Acetylcholinesterase--chemistry
Alzheimer Disease--drug therapy
Blood-Brain Barrier--metabolism
Cell Survival--drug effects
Cholinesterase Inhibitors--chemical synthesis
Drug Design
Hep G2 Cells
Humans
Indoles--chemical synthesis
Inhibitory Concentration 50
Ligands
Monoamine Oxidase--chemistry
Monoamine Oxidase Inhibitors--chemical synthesis
Quinolines--chemical synthesis
Structure-Activity Relationship
Tacrine--chemistry
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease. [electronic resource] - ChemMedChem 06 2016 - 1264-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1860-7187
10.1002/cmdc.201500383 doi
Acetylcholinesterase--chemistry
Alzheimer Disease--drug therapy
Blood-Brain Barrier--metabolism
Cell Survival--drug effects
Cholinesterase Inhibitors--chemical synthesis
Drug Design
Hep G2 Cells
Humans
Indoles--chemical synthesis
Inhibitory Concentration 50
Ligands
Monoamine Oxidase--chemistry
Monoamine Oxidase Inhibitors--chemical synthesis
Quinolines--chemical synthesis
Structure-Activity Relationship
Tacrine--chemistry