PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.

Prahallad, Anirudh

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs. [electronic resource] - Cell reports Sep 2015 - 1978-85 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2015.08.037 doi


Animals
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Colonic Neoplasms--drug therapy
Drug Resistance, Neoplasm--drug effects
ErbB Receptors--genetics
Gene Expression Regulation, Neoplastic
Genetic Vectors
Genomic Library
High-Throughput Nucleotide Sequencing
Humans
Indoles--pharmacology
Lentivirus--genetics
MAP Kinase Signaling System
Melanoma--drug therapy
Mice
Mice, Inbred NOD
Protein Tyrosine Phosphatase, Non-Receptor Type 11--antagonists & inhibitors
Proto-Oncogene Proteins B-raf--genetics
RNA, Small Interfering--genetics
Sulfonamides--pharmacology
Transduction, Genetic
Vemurafenib
Xenograft Model Antitumor Assays
ras Proteins--genetics