Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production.
Dittmann, Klaus
Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production. [electronic resource] - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Sep 2015 - 431-7 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1879-0887
10.1016/j.radonc.2015.08.016 doi
Blotting, Western
Bronchial Neoplasms--metabolism
Cell Line, Tumor
Cell Nucleus--metabolism
Dasatinib--pharmacology
ErbB Receptors--antagonists & inhibitors
Erlotinib Hydrochloride--pharmacology
Gene Expression
Head and Neck Neoplasms--metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Lactic Acid--biosynthesis
Nuclear Proteins--metabolism
Oxadiazoles--pharmacology
Protein Kinase Inhibitors--pharmacology
Pyrazoles--pharmacology
RNA, Messenger--metabolism
Radiation Tolerance--drug effects
Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production. [electronic resource] - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Sep 2015 - 431-7 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1879-0887
10.1016/j.radonc.2015.08.016 doi
Blotting, Western
Bronchial Neoplasms--metabolism
Cell Line, Tumor
Cell Nucleus--metabolism
Dasatinib--pharmacology
ErbB Receptors--antagonists & inhibitors
Erlotinib Hydrochloride--pharmacology
Gene Expression
Head and Neck Neoplasms--metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Lactic Acid--biosynthesis
Nuclear Proteins--metabolism
Oxadiazoles--pharmacology
Protein Kinase Inhibitors--pharmacology
Pyrazoles--pharmacology
RNA, Messenger--metabolism
Radiation Tolerance--drug effects