Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux.

Giuliano, Sandy

Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. [electronic resource] - Autophagy 2015 - 1891-904 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1554-8635

10.1080/15548627.2015.1085742 doi


Angiogenesis Inhibitors--pharmacology
Autophagy--drug effects
Carcinoma, Renal Cell--drug therapy
Cell Line, Tumor
Drug Resistance, Neoplasm--drug effects
Humans
Indoles--pharmacology
Lysosomes--drug effects
Neoplasm Recurrence, Local--metabolism
Neovascularization, Pathologic--drug therapy
Pyrroles--pharmacology
Sunitinib
Vascular Endothelial Growth Factor A--metabolism