Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats.

Cardoso, Juciane Lauren Cavalcanti

Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats. [electronic resource] - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Oct 2015 - 99-105 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Study

1873-6351

10.1016/j.fct.2015.08.002 doi


Air Pollutants, Occupational--toxicity
Animals
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Atmosphere Exposure Chambers
Biofuels--toxicity
Biomarkers--blood
Biotransformation--drug effects
Cytochrome P-450 CYP3A--chemistry
Cytochrome P-450 Enzyme Inducers--toxicity
Cytochrome P-450 Enzyme Inhibitors--blood
Cytochrome P-450 Enzyme System--chemistry
Enzyme Induction--drug effects
Ethanol--toxicity
Fluoxetine--blood
Ibuprofen--blood
Inhalation Exposure--adverse effects
Limonene Hydroxylases--antagonists & inhibitors
Male
Rats, Wistar
Toxicity Tests, Chronic--methods
Verapamil--analogs & derivatives