Tanshinone IIA represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-κB/p38/JNK signaling.

Li, Wei

Tanshinone IIA represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-κB/p38/JNK signaling. [electronic resource] - International immunopharmacology Sep 2015 - 382-9 p. digital

Publication Type: Journal Article

1878-1705

10.1016/j.intimp.2015.06.032 doi


Abietanes--pharmacology
Analgesics--pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Cell Survival--drug effects
Cells, Cultured
Cyclooxygenase 2--genetics
Drugs, Chinese Herbal--pharmacology
Female
Humans
Interleukin-1 Receptor-Associated Kinases--metabolism
Interleukin-1beta
Intervertebral Disc--cytology
Intervertebral Disc Degeneration--drug therapy
Intervertebral Disc Displacement--drug therapy
JNK Mitogen-Activated Protein Kinases--metabolism
Matrix Metalloproteinase 1--genetics
Matrix Metalloproteinase 13--genetics
NF-kappa B--metabolism
Nitric Oxide Synthase Type II--genetics
Pain--drug therapy
Rats, Sprague-Dawley
p38 Mitogen-Activated Protein Kinases--metabolism