The -308 TNFα and the -174 IL-6 promoter polymorphisms associate with effective anti-TNFα treatment in seronegative spondyloarthritis.
Fabris, M
The -308 TNFα and the -174 IL-6 promoter polymorphisms associate with effective anti-TNFα treatment in seronegative spondyloarthritis. [electronic resource] - The pharmacogenomics journal 06 2016 - 238-42 p. digital
Publication Type: Journal Article; Multicenter Study
1473-1150
10.1038/tpj.2015.49 doi
Adult
Aged
Aged, 80 and over
Antirheumatic Agents--adverse effects
Biological Products--adverse effects
Chi-Square Distribution
Drug Substitution
Female
Genetic Association Studies
Homozygote
Humans
Interleukin-6--genetics
Italy
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Pharmacogenomic Testing
Pharmacogenomic Variants--genetics
Phenotype
Polymorphism, Single Nucleotide
Predictive Value of Tests
Promoter Regions, Genetic
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Spondylarthritis--blood
Time Factors
Treatment Failure
Tumor Necrosis Factor-alpha--antagonists & inhibitors
Young Adult
The -308 TNFα and the -174 IL-6 promoter polymorphisms associate with effective anti-TNFα treatment in seronegative spondyloarthritis. [electronic resource] - The pharmacogenomics journal 06 2016 - 238-42 p. digital
Publication Type: Journal Article; Multicenter Study
1473-1150
10.1038/tpj.2015.49 doi
Adult
Aged
Aged, 80 and over
Antirheumatic Agents--adverse effects
Biological Products--adverse effects
Chi-Square Distribution
Drug Substitution
Female
Genetic Association Studies
Homozygote
Humans
Interleukin-6--genetics
Italy
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Pharmacogenomic Testing
Pharmacogenomic Variants--genetics
Phenotype
Polymorphism, Single Nucleotide
Predictive Value of Tests
Promoter Regions, Genetic
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Spondylarthritis--blood
Time Factors
Treatment Failure
Tumor Necrosis Factor-alpha--antagonists & inhibitors
Young Adult