Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.

Wu, Haodi

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. [electronic resource] - Cell stem cell Jul 2015 - 89-100 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1875-9777

10.1016/j.stem.2015.04.020 doi


Adrenergic beta-Agonists--pharmacology
Cardiomyopathy, Dilated--genetics
Cell Differentiation
Cells, Cultured
Cyclic Nucleotide Phosphodiesterases, Type 2--genetics
Cyclic Nucleotide Phosphodiesterases, Type 3--genetics
Epigenesis, Genetic
Heart Rate--drug effects
Humans
Induced Pluripotent Stem Cells--drug effects
Isoproterenol--pharmacology
Models, Cardiovascular
Mutant Proteins--genetics
Mutation
Myocardial Contraction--drug effects
Myocytes, Cardiac--drug effects
Receptors, Adrenergic, beta--metabolism
Signal Transduction
Troponin T--genetics
Up-Regulation