TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response.
Rozanov, Dmitri
TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response. [electronic resource] - PloS one 2015 - e0129566 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1932-6203
10.1371/journal.pone.0129566 doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Dose-Response Relationship, Drug
Doxorubicin--pharmacology
Drug Discovery
Glutathione--metabolism
Glutathione Reductase--antagonists & inhibitors
High-Throughput Screening Assays
Humans
Mice
Oxidative Stress
Reactive Oxygen Species
Small Molecule Libraries
TNF-Related Apoptosis-Inducing Ligand--metabolism
TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response. [electronic resource] - PloS one 2015 - e0129566 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1932-6203
10.1371/journal.pone.0129566 doi
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Dose-Response Relationship, Drug
Doxorubicin--pharmacology
Drug Discovery
Glutathione--metabolism
Glutathione Reductase--antagonists & inhibitors
High-Throughput Screening Assays
Humans
Mice
Oxidative Stress
Reactive Oxygen Species
Small Molecule Libraries
TNF-Related Apoptosis-Inducing Ligand--metabolism