Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.

Moody, David E

Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism. [electronic resource] - Journal of analytical toxicology Jun 2015 - 374-86 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

1945-2403

10.1093/jat/bkv030 doi


Administration, Oral
Analgesics, Opioid--metabolism
Antifungal Agents--administration & dosage
Azoles--administration & dosage
Biotransformation
Buprenorphine--metabolism
Chromatography, Liquid
Cytochrome P-450 Enzyme Inhibitors--administration & dosage
Cytochrome P-450 Enzyme System--metabolism
Dose-Response Relationship, Drug
Drug Interactions
Humans
Isoenzymes
Kinetics
Liver--drug effects
Methadone--metabolism
Microsomes, Liver--drug effects
Models, Biological
Molecular Structure
Oxycodone--metabolism
Recombinant Proteins--metabolism
Risk Assessment
Spectrometry, Mass, Electrospray Ionization
Structure-Activity Relationship
Substrate Specificity
Tandem Mass Spectrometry