PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth.
Abu Aboud, Omran
PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. [electronic resource] - American journal of physiology. Cell physiology Jun 2015 - C890-8 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1522-1563
10.1152/ajpcell.00322.2014 doi
Animals
Carcinoma, Renal Cell--drug therapy
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
Epithelial Cells--drug effects
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms--drug therapy
Kidney Tubules--drug effects
Metabolic Networks and Pathways--drug effects
Mice
Mice, Nude
Organ Specificity
Oxazoles--pharmacology
PPAR alpha--antagonists & inhibitors
Phosphorylation--drug effects
Proto-Oncogene Proteins c-myc--antagonists & inhibitors
RNA, Small Interfering--genetics
Signal Transduction
Tyrosine--analogs & derivatives
Xenograft Model Antitumor Assays
PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. [electronic resource] - American journal of physiology. Cell physiology Jun 2015 - C890-8 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1522-1563
10.1152/ajpcell.00322.2014 doi
Animals
Carcinoma, Renal Cell--drug therapy
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
Epithelial Cells--drug effects
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms--drug therapy
Kidney Tubules--drug effects
Metabolic Networks and Pathways--drug effects
Mice
Mice, Nude
Organ Specificity
Oxazoles--pharmacology
PPAR alpha--antagonists & inhibitors
Phosphorylation--drug effects
Proto-Oncogene Proteins c-myc--antagonists & inhibitors
RNA, Small Interfering--genetics
Signal Transduction
Tyrosine--analogs & derivatives
Xenograft Model Antitumor Assays