MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.
Kovatcheva, Marta
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. [electronic resource] - Oncotarget Apr 2015 - 8226-43 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.3364 doi
Breast Neoplasms--metabolism
Cell Line, Tumor
Cellular Senescence
Cyclin-Dependent Kinase 4--antagonists & inhibitors
DNA Helicases--biosynthesis
Gene Knockdown Techniques
Humans
Liposarcoma
Nuclear Proteins--biosynthesis
Phosphorylation
Piperazines--pharmacology
Proto-Oncogene Proteins c-mdm2--metabolism
Pyridines--pharmacology
Retinoblastoma Protein--metabolism
X-linked Nuclear Protein
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. [electronic resource] - Oncotarget Apr 2015 - 8226-43 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.3364 doi
Breast Neoplasms--metabolism
Cell Line, Tumor
Cellular Senescence
Cyclin-Dependent Kinase 4--antagonists & inhibitors
DNA Helicases--biosynthesis
Gene Knockdown Techniques
Humans
Liposarcoma
Nuclear Proteins--biosynthesis
Phosphorylation
Piperazines--pharmacology
Proto-Oncogene Proteins c-mdm2--metabolism
Pyridines--pharmacology
Retinoblastoma Protein--metabolism
X-linked Nuclear Protein