Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages.

Ueno, Manabu

Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages. [electronic resource] - Nature communications Mar 2015 - 6332 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/ncomms7332 doi


Administration, Inhalation
Aerosols
Alendronate--pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Antigens, Differentiation--genetics
Apoptosis--drug effects
Bone Density Conservation Agents--pharmacology
Bronchoalveolar Lavage Fluid--chemistry
CD11b Antigen--genetics
CD11c Antigen--genetics
Caspase 3--genetics
Cell Movement--drug effects
Contrast Media--metabolism
Drug Repositioning
Gene Expression
Lung--drug effects
Macrophages, Alveolar--drug effects
Male
Mevalonic Acid--immunology
Mice
Mice, Inbred C57BL
NF-kappa B--genetics
Pancreatic Elastase
Phagocytosis--drug effects
Pulmonary Emphysema--chemically induced
Signal Transduction