Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
Kettle, Jason G
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. [electronic resource] - Journal of medicinal chemistry Mar 2015 - 2834-44 p. digital
Publication Type: Journal Article
1520-4804
10.1021/acs.jmedchem.5b00098 doi
Animals
COS Cells
Cell Line, Tumor
Chlorocebus aethiops
Drug Discovery
Drug Resistance
Humans
MAP Kinase Kinase Kinases--antagonists & inhibitors
Models, Molecular
Protein Kinase Inhibitors--chemistry
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
RNA Interference
RNA, Small Interfering--genetics
Rats, Wistar
Dyrk Kinases
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. [electronic resource] - Journal of medicinal chemistry Mar 2015 - 2834-44 p. digital
Publication Type: Journal Article
1520-4804
10.1021/acs.jmedchem.5b00098 doi
Animals
COS Cells
Cell Line, Tumor
Chlorocebus aethiops
Drug Discovery
Drug Resistance
Humans
MAP Kinase Kinase Kinases--antagonists & inhibitors
Models, Molecular
Protein Kinase Inhibitors--chemistry
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
RNA Interference
RNA, Small Interfering--genetics
Rats, Wistar
Dyrk Kinases