Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway.
Wu, Qing-Qing
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway. [electronic resource] - American journal of physiology. Heart and circulatory physiology May 2015 - H1143-54 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-1539
10.1152/ajpheart.00601.2014 doi
Animals
Apoptosis
Cathepsin B--antagonists & inhibitors
Disease Models, Animal
Female
Fibrosis
HEK293 Cells
Humans
Hypertrophy, Left Ventricular--enzymology
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
MAP Kinase Kinase Kinase 5--metabolism
Male
Mice, Knockout
Myocytes, Cardiac--drug effects
Protein Kinase Inhibitors--pharmacology
RNA Interference
Signal Transduction
Transfection
Tumor Necrosis Factor-alpha--metabolism
Ventricular Function, Left--drug effects
Ventricular Remodeling--drug effects
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway. [electronic resource] - American journal of physiology. Heart and circulatory physiology May 2015 - H1143-54 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-1539
10.1152/ajpheart.00601.2014 doi
Animals
Apoptosis
Cathepsin B--antagonists & inhibitors
Disease Models, Animal
Female
Fibrosis
HEK293 Cells
Humans
Hypertrophy, Left Ventricular--enzymology
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
MAP Kinase Kinase Kinase 5--metabolism
Male
Mice, Knockout
Myocytes, Cardiac--drug effects
Protein Kinase Inhibitors--pharmacology
RNA Interference
Signal Transduction
Transfection
Tumor Necrosis Factor-alpha--metabolism
Ventricular Function, Left--drug effects
Ventricular Remodeling--drug effects