Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.

Sisson, Thomas H

Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis. [electronic resource] - The American journal of pathology Apr 2015 - 969-86 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1525-2191

10.1016/j.ajpath.2014.12.005 doi


Adult
Alveolar Epithelial Cells--drug effects
Animals
Apoptosis--drug effects
Cell Differentiation--drug effects
Cell Nucleus--drug effects
Cytoprotection--drug effects
Fibronectins--metabolism
Fibrosis
Humans
Inflammation--pathology
Lung--metabolism
Mesoderm--drug effects
Mice, Inbred C57BL
Myofibroblasts--pathology
Nipecotic Acids--administration & dosage
Plasminogen Activator Inhibitor 1--metabolism
Protein Transport--drug effects
Serum Response Factor--metabolism
Signal Transduction--drug effects
Sus scrofa
Trans-Activators--metabolism
Transforming Growth Factor beta1--pharmacology
X-Linked Inhibitor of Apoptosis Protein--metabolism
fas Receptor--metabolism