Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.

Jin, Nana

Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. [electronic resource] - Scientific reports Feb 2015 - 8187 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2045-2322

10.1038/srep08187 doi


Alzheimer Disease--metabolism
Animals
Brain--drug effects
Calcium--metabolism
Calpain--metabolism
Glycogen Synthase Kinase 3--genetics
Glycogen Synthase Kinase 3 beta
HEK293 Cells
Humans
Kainic Acid--toxicity
Male
Mice
Phosphorylation--drug effects
Proteolysis
Recombinant Fusion Proteins--genetics
Up-Regulation--drug effects
tau Proteins--metabolism