High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis.

Manzano-Moreno, Francisco Javier

High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis. [electronic resource] - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery Apr 2015 - 396-401 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1878-4119

10.1016/j.jcms.2014.12.008 doi


Alendronate--administration & dosage
Apoptosis--drug effects
Bisphosphonate-Associated Osteonecrosis of the Jaw--pathology
Bone Density Conservation Agents--administration & dosage
Cell Cycle--drug effects
Cell Death--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Clodronic Acid--administration & dosage
Coloring Agents
Diphosphonates--administration & dosage
Dose-Response Relationship, Drug
Flow Cytometry--methods
G1 Phase--drug effects
Humans
Ibandronic Acid
Necrosis
Osteoblasts--drug effects
Pamidronate
Resting Phase, Cell Cycle--drug effects
Spectrophotometry--methods
Tetrazolium Salts
Thiazoles
Time Factors