Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
Majumder, Kinjal
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. [electronic resource] - The Journal of experimental medicine Jan 2015 - 107-20 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1540-9538
10.1084/jem.20141479 doi
Animals
CCCTC-Binding Factor
Cell Lineage--genetics
Cells, Cultured
Chromatin--genetics
Enhancer Elements, Genetic--genetics
Gene Expression Regulation
Histones--metabolism
In Situ Hybridization, Fluorescence--methods
Methylation
Mice, Inbred C57BL
Mice, Knockout
Precursor Cells, B-Lymphoid--cytology
Promoter Regions, Genetic--genetics
Protein Binding
Receptors, Antigen, T-Cell, alpha-beta--genetics
Repressor Proteins--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Thymocytes--cytology
V(D)J Recombination--genetics
VDJ Recombinases--metabolism
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. [electronic resource] - The Journal of experimental medicine Jan 2015 - 107-20 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1540-9538
10.1084/jem.20141479 doi
Animals
CCCTC-Binding Factor
Cell Lineage--genetics
Cells, Cultured
Chromatin--genetics
Enhancer Elements, Genetic--genetics
Gene Expression Regulation
Histones--metabolism
In Situ Hybridization, Fluorescence--methods
Methylation
Mice, Inbred C57BL
Mice, Knockout
Precursor Cells, B-Lymphoid--cytology
Promoter Regions, Genetic--genetics
Protein Binding
Receptors, Antigen, T-Cell, alpha-beta--genetics
Repressor Proteins--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Thymocytes--cytology
V(D)J Recombination--genetics
VDJ Recombinases--metabolism