Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.

Duan, Lei

Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. [electronic resource] - Cancer biology & therapy 2014 - 1600-12 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1555-8576

10.4161/15384047.2014.961876 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
Checkpoint Kinase 1
Cisplatin--pharmacology
Cyclin-Dependent Kinase Inhibitor p27--genetics
DNA Damage--drug effects
Drug Resistance, Neoplasm
Enzyme Activation
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Heterocyclic Compounds, 3-Ring--pharmacology
Humans
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Protein Kinases--metabolism
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
RNA Interference
RNA, Small Interfering--genetics
Tumor Suppressor Protein p53--genetics