Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone.
Wu, Xue-Feng
Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. [electronic resource] - Toxicology and applied pharmacology 11 2014 - 146-56 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1096-0333
10.1016/j.taap.2014.10.002 doi
Animals
Benzofurans--pharmacology
Cell Line
Colitis--chemically induced
Dextran Sulfate--toxicity
Disease Models, Animal
Dose-Response Relationship, Drug
Humans
Inflammasomes--antagonists & inhibitors
Macrophages, Peritoneal--drug effects
Male
Mice
Mice, Inbred C57BL
NF-kappa B--antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein--antagonists & inhibitors
Signal Transduction--drug effects
Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. [electronic resource] - Toxicology and applied pharmacology 11 2014 - 146-56 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1096-0333
10.1016/j.taap.2014.10.002 doi
Animals
Benzofurans--pharmacology
Cell Line
Colitis--chemically induced
Dextran Sulfate--toxicity
Disease Models, Animal
Dose-Response Relationship, Drug
Humans
Inflammasomes--antagonists & inhibitors
Macrophages, Peritoneal--drug effects
Male
Mice
Mice, Inbred C57BL
NF-kappa B--antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein--antagonists & inhibitors
Signal Transduction--drug effects