Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.
Li, Rongshi
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors. [electronic resource] - European journal of medicinal chemistry Jan 2015 - 315-331 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2014.11.035 doi
Apoptosis Regulatory Proteins--metabolism
Binding Sites--drug effects
Dose-Response Relationship, Drug
Drug Design
Humans
Molecular Structure
Myeloid Cell Leukemia Sequence 1 Protein--antagonists & inhibitors
Pyrroles--chemical synthesis
Structure-Activity Relationship
bcl-X Protein--antagonists & inhibitors
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors. [electronic resource] - European journal of medicinal chemistry Jan 2015 - 315-331 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2014.11.035 doi
Apoptosis Regulatory Proteins--metabolism
Binding Sites--drug effects
Dose-Response Relationship, Drug
Drug Design
Humans
Molecular Structure
Myeloid Cell Leukemia Sequence 1 Protein--antagonists & inhibitors
Pyrroles--chemical synthesis
Structure-Activity Relationship
bcl-X Protein--antagonists & inhibitors