Peptidylarginine deiminase inhibition impairs Toll-like receptor agonist-induced functional maturation of dendritic cells, resulting in the loss of T cell-proliferative capacity: a partial mechanism with therapeutic potential in inflammatory settings.

Jang, Byungki

Peptidylarginine deiminase inhibition impairs Toll-like receptor agonist-induced functional maturation of dendritic cells, resulting in the loss of T cell-proliferative capacity: a partial mechanism with therapeutic potential in inflammatory settings. [electronic resource] - Journal of leukocyte biology Feb 2015 - 351-62 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1938-3673

10.1189/jlb.3A0314-142RR doi


Animals
B7-1 Antigen--immunology
CD4-Positive T-Lymphocytes--immunology
CD8-Positive T-Lymphocytes--immunology
Cell Proliferation--drug effects
Cytokines--immunology
Dendritic Cells--immunology
Female
Hydrolases--antagonists & inhibitors
Inflammation--chemically induced
Lipopolysaccharides--toxicity
MAP Kinase Signaling System--drug effects
Mice
NF-kappa B--pharmacology
Ornithine--analogs & derivatives
Protein-Arginine Deiminases
Toll-Like Receptors--agonists