Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.

Yang, Nae-Cherng

Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells. [electronic resource] - Biogerontology Feb 2015 - 31-42 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1573-6768

10.1007/s10522-014-9528-x doi


Acrylamides--pharmacology
Benzamides--pharmacology
Cell Line
Cell Proliferation--drug effects
Cell Survival--drug effects
Cells, Cultured
Cellular Senescence--drug effects
Cytokines--antagonists & inhibitors
Dose-Response Relationship, Drug
Fibroblasts--cytology
Glucose--pharmacology
Humans
NAD--metabolism
Naphthols--pharmacology
Niacinamide--metabolism
Nicotinamide Phosphoribosyltransferase--antagonists & inhibitors
Piperidines--pharmacology
Sirtuin 1--antagonists & inhibitors
Up-Regulation--drug effects