Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

Horikawa, Izumi

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence. [electronic resource] - Nature communications Aug 2014 - 4706 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

2041-1723

10.1038/ncomms5706 doi


Adaptor Proteins, Signal Transducing--genetics
Androstadienes--pharmacology
Apoptosis Regulatory Proteins--genetics
Autophagy--drug effects
Beclin-1
Cells, Cultured
Cellular Senescence--physiology
Cycloheximide--pharmacology
Fibroblasts--drug effects
Gene Knockdown Techniques
Humans
Membrane Proteins--genetics
Microtubule-Associated Proteins--genetics
Protein Isoforms--metabolism
RNA, Small Interfering
Sequestosome-1 Protein
Tumor Suppressor Protein p53--genetics
Ubiquitin-Protein Ligases--genetics
Wortmannin