A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

Lewis, Annabelle

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding. [electronic resource] - Cell reports Aug 2014 - 983-90 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2014.07.020 doi


Animals
Base Sequence
CDX2 Transcription Factor
Cell Line, Tumor
Colonic Neoplasms--genetics
Enhancer Elements, Genetic
Gene Expression Regulation, Neoplastic
Genetic Association Studies
Genetic Predisposition to Disease
Homeodomain Proteins--metabolism
Humans
Intercellular Signaling Peptides and Proteins--genetics
Mice, Transgenic
Organ Specificity
Polymorphism, Single Nucleotide
Risk
Transcription Factor 7-Like 2 Protein--metabolism