Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

Wang, Chelsia Qiuxia

Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects. [electronic resource] - Cell reports Aug 2014 - 767-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2014.06.046 doi


Animals
Bone Marrow--metabolism
Core Binding Factor Alpha 2 Subunit--genetics
Core Binding Factor Alpha 3 Subunit--genetics
DNA Repair
Fanconi Anemia--genetics
Fanconi Anemia Complementation Group D2 Protein--metabolism
Gene Deletion
Genetic Predisposition to Disease
HCT116 Cells
HEK293 Cells
HeLa Cells
Humans
Leukemia--genetics
Mice
Mice, Inbred C57BL