Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.

Cazes, Alex

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma. [electronic resource] - Oncotarget May 2014 - 2688-702 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.1883 doi


Amino Acid Sequence
Anaplastic Lymphoma Kinase
Animals
Base Sequence
Biomarkers, Tumor--genetics
Blotting, Southern
Blotting, Western
Cell Transformation, Neoplastic--genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Integrases
Mice
Mice, Inbred C57BL
Mice, Transgenic
Molecular Sequence Data
Mutation--genetics
N-Myc Proto-Oncogene Protein
Neuroblastoma--genetics
Neurogenesis
Oligonucleotide Array Sequence Analysis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret--genetics
RNA, Messenger--genetics
Real-Time Polymerase Chain Reaction
Receptor Protein-Tyrosine Kinases--genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
Transcriptional Activation
Tumor Cells, Cultured