The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer.

Chuang, C-H

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer. [electronic resource] - Cell death & disease May 2014 - e1220 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/cddis.2014.106 doi


Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
BALB 3T3 Cells
Binding Sites
CCAAT-Enhancer-Binding Protein-delta--pharmacology
Caspase 3--metabolism
Caspase 8--genetics
Cell Line, Tumor
Cell Proliferation--drug effects
E2F1 Transcription Factor--genetics
Enhancer of Zeste Homolog 2 Protein
Enzyme Activation
Gene Expression Regulation, Neoplastic
Genes, Reporter
Granzymes--pharmacology
Humans
Male
Mice
Neoplasm Proteins
Perforin--pharmacology
Polycomb Repressive Complex 2--genetics
Prodrugs--metabolism
Promoter Regions, Genetic
Prostatic Neoplasms--enzymology
Receptors, Androgen--drug effects
Recombinant Fusion Proteins--pharmacology
Signal Transduction--drug effects
Time Factors
Transcription Factors
Transfection