Anti-neoplastic activity of low-dose endothelial-monocyte activating polypeptide-II results from defective autophagy and G2/M arrest mediated by PI3K/Akt/FoxO1 axis in human glioblastoma stem cells.

Liu, Jing

Anti-neoplastic activity of low-dose endothelial-monocyte activating polypeptide-II results from defective autophagy and G2/M arrest mediated by PI3K/Akt/FoxO1 axis in human glioblastoma stem cells. [electronic resource] - Biochemical pharmacology Jun 2014 - 477-89 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-2968

10.1016/j.bcp.2014.04.014 doi


Animals
Antineoplastic Agents--antagonists & inhibitors
Autophagy--drug effects
Brain Neoplasms--drug therapy
Cell Line, Tumor
Cytokines--antagonists & inhibitors
Forkhead Box Protein O1
Forkhead Transcription Factors--agonists
G2 Phase--drug effects
Glioblastoma--drug therapy
Humans
Male
Mice
Mice, Nude
Neoplasm Proteins--agonists
Neoplastic Stem Cells--drug effects
Nerve Tissue Proteins--agonists
Neurons--drug effects
Phosphatidylinositol 3-Kinase--chemistry
RNA Interference
RNA-Binding Proteins--antagonists & inhibitors
Random Allocation
Recombinant Proteins--pharmacology
Second Messenger Systems--drug effects
Tumor Burden--drug effects
Xenograft Model Antitumor Assays