p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.

Zheng, Fang

p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine. [electronic resource] - Journal of experimental & clinical cancer research : CR Apr 2014 - 36 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1756-9966

10.1186/1756-9966-33-36 doi


Adenocarcinoma
Adenocarcinoma of Lung
Antineoplastic Agents--pharmacology
Apoptosis
Berberine--pharmacology
Cell Line, Tumor
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p21--genetics
Forkhead Box Protein O3
Forkhead Transcription Factors--genetics
G1 Phase Cell Cycle Checkpoints--drug effects
Gene Expression
Gene Expression Regulation, Neoplastic--drug effects
Humans
Lung Neoplasms
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase 14--physiology
Phosphorylation
Protein Processing, Post-Translational
Transcriptional Activation
Tumor Suppressor Protein p53--genetics