Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.
Videnović, Milica
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria. [electronic resource] - Journal of medicinal chemistry May 2014 - 4134-53 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm500033r doi
Aminoquinolines--chemical synthesis
Animals
Antimalarials--chemical synthesis
Botulinum Toxins, Type A--antagonists & inhibitors
Chick Embryo
Chloroquine--pharmacology
Drug Resistance
Hep G2 Cells
Humans
Metalloproteases--drug effects
Molecular Docking Simulation
Plasmodium falciparum--drug effects
Protease Inhibitors--chemical synthesis
Structure-Activity Relationship
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria. [electronic resource] - Journal of medicinal chemistry May 2014 - 4134-53 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm500033r doi
Aminoquinolines--chemical synthesis
Animals
Antimalarials--chemical synthesis
Botulinum Toxins, Type A--antagonists & inhibitors
Chick Embryo
Chloroquine--pharmacology
Drug Resistance
Hep G2 Cells
Humans
Metalloproteases--drug effects
Molecular Docking Simulation
Plasmodium falciparum--drug effects
Protease Inhibitors--chemical synthesis
Structure-Activity Relationship