Supplementation of ketoacids contributes to the up-regulation of the Wnt7a/Akt/p70S6K pathway and the down-regulation of apoptotic and ubiquitin-proteasome systems in the muscle of 5/6 nephrectomised rats.

Wang, Dong-Tao

Supplementation of ketoacids contributes to the up-regulation of the Wnt7a/Akt/p70S6K pathway and the down-regulation of apoptotic and ubiquitin-proteasome systems in the muscle of 5/6 nephrectomised rats. [electronic resource] - The British journal of nutrition May 2014 - 1536-48 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1475-2662

10.1017/S0007114513004091 doi


Animals
Apoptosis
Diet, Protein-Restricted--adverse effects
Dietary Supplements
Disease Models, Animal
Down-Regulation
Keto Acids--therapeutic use
Male
Muscle Proteins--biosynthesis
Muscle, Skeletal--metabolism
Muscular Atrophy--etiology
Nephrectomy--adverse effects
Proteasome Endopeptidase Complex--metabolism
Proteolysis
Proto-Oncogene Proteins--agonists
Random Allocation
Rats
Rats, Sprague-Dawley
Renal Insufficiency, Chronic--diet therapy
Signal Transduction
Ubiquitination
Up-Regulation
Wnt Proteins--agonists