Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease.

Neves, Adriane R

Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease. [electronic resource] - Inflammatory bowel diseases Mar 2014 - 444-57 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1536-4844

10.1097/01.MIB.0000441201.10454.06 doi


Adenosine Triphosphate--metabolism
Adolescent
Adult
Animals
Apoptosis
Blotting, Western
Case-Control Studies
Colitis, Ulcerative--genetics
Colonoscopy
Crohn Disease--genetics
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Follow-Up Studies
Humans
Interferon-gamma--metabolism
Interleukin-10--genetics
Interleukin-1beta--genetics
Intestinal Mucosa--metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Prognosis
RNA, Messenger--genetics
Real-Time Polymerase Chain Reaction
Receptors, Purinergic P2X7--physiology
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha--genetics
Young Adult