Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis.

Kazgan, Nevzat

Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis. [electronic resource] - Gastroenterology Apr 2014 - 1006-16 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

1528-0012

10.1053/j.gastro.2013.12.029 doi


Animals
Bile Acids and Salts--metabolism
Cholesterol, Dietary--metabolism
Cholic Acid--metabolism
Feces--chemistry
Guanine Nucleotide Exchange Factors--metabolism
Hepatocyte Nuclear Factor 1-alpha--metabolism
Homeostasis
Hydro-Lyases--metabolism
Ileum--enzymology
Intestinal Absorption
Intestines--enzymology
Liver--enzymology
Mice
Mice, Inbred C57BL
Mice, Knockout
Organic Anion Transporters, Sodium-Dependent--metabolism
Receptors, Cytoplasmic and Nuclear--metabolism
Rho Guanine Nucleotide Exchange Factors
Signal Transduction
Sirtuin 1--deficiency
Symporters--metabolism