Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.

Lamphier, Marc

Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. [electronic resource] - Molecular pharmacology Mar 2014 - 429-40 p. digital

Publication Type: Journal Article

1521-0111

10.1124/mol.113.089821 doi


AMP-Activated Protein Kinases--genetics
Animals
Carrier Proteins--genetics
Cell Line
Down-Regulation--drug effects
Doxorubicin--pharmacology
MAP Kinase Kinase Kinase 5--genetics
Membrane Glycoproteins--antagonists & inhibitors
Mice
Oxidative Stress--drug effects
Podocytes--drug effects
Reactive Oxygen Species--metabolism
Signal Transduction--drug effects
Small Molecule Libraries--pharmacokinetics
Thioredoxins--genetics
Toll-Like Receptor 7--antagonists & inhibitors
Toll-Like Receptor 9--antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases--genetics