YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA.
Chang, Y-W
YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA. [electronic resource] - Oncogene Oct 2014 - 5065-77 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2013.450 doi
Binding Sites
DNA Mismatch Repair
DNA-Binding Proteins--metabolism
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
HeLa Cells
Humans
Methylnitronitrosoguanidine--pharmacology
Microsatellite Instability
MutS Homolog 2 Protein--metabolism
Mutation
Proliferating Cell Nuclear Antigen--chemistry
Protein Structure, Quaternary
Protein Structure, Tertiary
Y-Box-Binding Protein 1--chemistry
YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA. [electronic resource] - Oncogene Oct 2014 - 5065-77 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2013.450 doi
Binding Sites
DNA Mismatch Repair
DNA-Binding Proteins--metabolism
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
HeLa Cells
Humans
Methylnitronitrosoguanidine--pharmacology
Microsatellite Instability
MutS Homolog 2 Protein--metabolism
Mutation
Proliferating Cell Nuclear Antigen--chemistry
Protein Structure, Quaternary
Protein Structure, Tertiary
Y-Box-Binding Protein 1--chemistry