Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier.

Rom, Slava

Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier. [electronic resource] - The American journal of pathology Nov 2013 - 1548-1558 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

1525-2191

10.1016/j.ajpath.2013.07.033 doi


Actin Depolymerizing Factors--metabolism
Animals
Blood-Brain Barrier--metabolism
Cell Adhesion
Cell Adhesion Molecules--metabolism
Cell Line
Cerebral Cortex--blood supply
Encephalitis--metabolism
Endothelial Cells--metabolism
Endothelium--metabolism
Humans
Integrin alpha4beta1--chemistry
Integrin beta1--metabolism
Leukocytes--metabolism
Lipopolysaccharides
Lymphocyte Function-Associated Antigen-1--chemistry
Mice
Microfilament Proteins--metabolism
Microvessels--pathology
Monocytes--metabolism
Phosphoproteins--metabolism
Phosphorylation
Pseudopodia--metabolism
Receptor, Cannabinoid, CB2--agonists
Transendothelial and Transepithelial Migration
rac1 GTP-Binding Protein--metabolism
rhoA GTP-Binding Protein
Vasodilator-Stimulated Phosphoprotein