The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors.

Chang, Xiaofei

The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors. [electronic resource] - PloS one 2013 - e68966 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0068966 doi


Adaptor Proteins, Signal Transducing--genetics
Animals
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Line, Tumor
Drug Resistance, Neoplasm--drug effects
ErbB Receptors--antagonists & inhibitors
Erlotinib Hydrochloride
Female
Gefitinib
Humans
Immunoblotting
Kaplan-Meier Estimate
Lung--drug effects
Lung Neoplasms--drug therapy
Male
Mice
Middle Aged
Phosphatidylinositol 3-Kinases--metabolism
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Quinazolines--pharmacology
RNA Interference
Signal Transduction--drug effects
Tumor Suppressor Proteins--genetics
Xenograft Model Antitumor Assays