Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-β receptor I internalization and inhibiting transforming growth factor-β1 signaling.

Shi, Yuanyuan

Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-β receptor I internalization and inhibiting transforming growth factor-β1 signaling. [electronic resource] - American journal of respiratory and critical care medicine Oct 2013 - 831-41 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1535-4970

10.1164/rccm.201303-0434OC doi


Animals
Apoptosis
Bleomycin--administration & dosage
Bronchoalveolar Lavage
Caveolin 1--drug effects
Disease Models, Animal
Gene Expression Profiling
Genetic Markers
Humans
Hydroxyproline--analysis
Idiopathic Pulmonary Fibrosis--chemically induced
In Vitro Techniques
Macrophages, Alveolar--drug effects
Mice
Mice, Transgenic
Signal Transduction
Syndecan-2--physiology
Tissue Array Analysis
Transforming Growth Factor beta1--drug effects
Up-Regulation--drug effects