Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs.

Chan, Jackie K W

Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs. [electronic resource] - Particle and fibre toxicology Aug 2013 - 34 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1743-8977

10.1186/1743-8977-10-34 doi


Age Factors
Animals
Animals, Newborn
Antioxidants--metabolism
Catalase--genetics
Dose-Response Relationship, Drug
Gene Expression Regulation, Enzymologic--drug effects
Genes, Reporter
Heme Oxygenase (Decyclizing)--genetics
Humans
Inhalation Exposure
Lung--drug effects
Male
NF-E2-Related Factor 2--genetics
Oxidative Stress--drug effects
Particle Size
Peroxiredoxin VI--genetics
RNA, Messenger--metabolism
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species--metabolism
Soot--toxicity
Superoxide Dismutase--genetics
Superoxide Dismutase-1
Time Factors
Transfection
U937 Cells