Inhibition of Wnt/β-catenin signaling downregulates P-glycoprotein and reverses multi-drug resistance of cholangiocarcinoma.

Shen, Dong-Yan

Inhibition of Wnt/β-catenin signaling downregulates P-glycoprotein and reverses multi-drug resistance of cholangiocarcinoma. [electronic resource] - Cancer science Oct 2013 - 1303-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1349-7006

10.1111/cas.12223 doi


ATP Binding Cassette Transporter, Subfamily B--biosynthesis
Alligators and Crocodiles
Animals
Antineoplastic Agents--pharmacology
Bile--chemistry
Bile Duct Neoplasms--genetics
Bile Ducts, Intrahepatic--metabolism
Cell Cycle
Cell Line, Tumor--drug effects
Cell Size
Cholangiocarcinoma--genetics
Down-Regulation--drug effects
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Humans
Neoplasm Proteins--antagonists & inhibitors
RNA Interference
RNA, Small Interfering--pharmacology
Real-Time Polymerase Chain Reaction
Tissue Extracts--pharmacology
Wnt Signaling Pathway--drug effects
Wnt3A Protein--pharmacology
beta Catenin--antagonists & inhibitors
ATP-Binding Cassette Sub-Family B Member 4