PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1.

Hou, Xiaoyang

PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1. [electronic resource] - European journal of pharmacology Sep 2013 - 196-203 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0712

10.1016/j.ejphar.2013.05.021 doi


Angiotensin II--pharmacology
Animals
Cell Differentiation--drug effects
Cell Proliferation--drug effects
Cell Survival--drug effects
Collagen Type I--genetics
Collagen Type III--genetics
Cyclin D1--genetics
Fibroblasts--cytology
JNK Mitogen-Activated Protein Kinases--chemistry
Myocardium--cytology
Myofibroblasts--cytology
PPAR gamma--metabolism
Phenotype
Protein Multimerization--drug effects
Protein Structure, Quaternary
Proto-Oncogene Proteins c-fos--chemistry
RNA, Messenger--genetics
Rats
Rats, Wistar
Rosiglitazone
Thiazolidinediones--pharmacology
Transcription Factor AP-1--metabolism
Transforming Growth Factor beta1--genetics