13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3.
Cai, Qingqing
13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3. [electronic resource] - PloS one 2013 - e65308 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0065308 doi
Animals
Apoptosis--drug effects
Blotting, Western
Caspase 3--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Down-Regulation--drug effects
Enzyme Activation--drug effects
G1 Phase Cell Cycle Checkpoints--drug effects
Lymphoma, T-Cell--drug therapy
Mice
Mice, Nude
Myristic Acids--administration & dosage
NF-kappa B--metabolism
Neoplasm Proteins--metabolism
Phosphorylation--drug effects
Poly(ADP-ribose) Polymerases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Xenograft Model Antitumor Assays
13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3. [electronic resource] - PloS one 2013 - e65308 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0065308 doi
Animals
Apoptosis--drug effects
Blotting, Western
Caspase 3--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Down-Regulation--drug effects
Enzyme Activation--drug effects
G1 Phase Cell Cycle Checkpoints--drug effects
Lymphoma, T-Cell--drug therapy
Mice
Mice, Nude
Myristic Acids--administration & dosage
NF-kappa B--metabolism
Neoplasm Proteins--metabolism
Phosphorylation--drug effects
Poly(ADP-ribose) Polymerases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Xenograft Model Antitumor Assays