Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway.
Iafrati, J
Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway. [electronic resource] - Molecular psychiatry Apr 2014 - 417-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5578
10.1038/mp.2013.66 doi
Analysis of Variance
Animals
Animals, Newborn
Cell Adhesion Molecules, Neuronal--deficiency
Conditioning, Classical--drug effects
Dendritic Spines--drug effects
Dose-Response Relationship, Drug
Excitatory Amino Acid Agents--pharmacology
Extinction, Psychological--drug effects
Extracellular Matrix Proteins--deficiency
Fear--drug effects
Female
In Vitro Techniques
Ketamine--pharmacology
Long-Term Potentiation--drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins--deficiency
Patch-Clamp Techniques
Phenols
Piperidines--pharmacology
Prefrontal Cortex--cytology
Receptors, N-Methyl-D-Aspartate--metabolism
Reelin Protein
Serine Endopeptidases--deficiency
Signal Transduction--drug effects
Sirolimus
TOR Serine-Threonine Kinases--metabolism
Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway. [electronic resource] - Molecular psychiatry Apr 2014 - 417-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5578
10.1038/mp.2013.66 doi
Analysis of Variance
Animals
Animals, Newborn
Cell Adhesion Molecules, Neuronal--deficiency
Conditioning, Classical--drug effects
Dendritic Spines--drug effects
Dose-Response Relationship, Drug
Excitatory Amino Acid Agents--pharmacology
Extinction, Psychological--drug effects
Extracellular Matrix Proteins--deficiency
Fear--drug effects
Female
In Vitro Techniques
Ketamine--pharmacology
Long-Term Potentiation--drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins--deficiency
Patch-Clamp Techniques
Phenols
Piperidines--pharmacology
Prefrontal Cortex--cytology
Receptors, N-Methyl-D-Aspartate--metabolism
Reelin Protein
Serine Endopeptidases--deficiency
Signal Transduction--drug effects
Sirolimus
TOR Serine-Threonine Kinases--metabolism