Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.

Hao, Yujun

Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. [electronic resource] - Cancer cell May 2013 - 583-93 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1878-3686

10.1016/j.ccr.2013.03.021 doi


Amino Acid Substitution
Cell Line, Tumor
Class I Phosphatidylinositol 3-Kinases
Humans
Insulin Receptor Substrate Proteins--chemistry
Neoplasms--genetics
Phosphatidylinositol 3-Kinases--chemistry
Phosphorylation
Protein Interaction Mapping
Protein Structure, Tertiary
Proto-Oncogene Proteins c-akt--metabolism