Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
Chaturvedula, Prasad V
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery. [electronic resource] - Bioorganic & medicinal chemistry letters Jun 2013 - 3157-61 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2013.04.012 doi
Administration, Intranasal
Amides--chemistry
Animals
Caco-2 Cells
Calcitonin Gene-Related Peptide Receptor Antagonists
Callithrix
Coronary Vessels--drug effects
Drug Evaluation, Preclinical
Face--blood supply
Humans
Indazoles--chemistry
Migraine Disorders--drug therapy
Quinolones--chemistry
Rabbits
Rats
Receptors, Calcitonin Gene-Related Peptide--metabolism
Respiratory Mucosa--drug effects
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery. [electronic resource] - Bioorganic & medicinal chemistry letters Jun 2013 - 3157-61 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2013.04.012 doi
Administration, Intranasal
Amides--chemistry
Animals
Caco-2 Cells
Calcitonin Gene-Related Peptide Receptor Antagonists
Callithrix
Coronary Vessels--drug effects
Drug Evaluation, Preclinical
Face--blood supply
Humans
Indazoles--chemistry
Migraine Disorders--drug therapy
Quinolones--chemistry
Rabbits
Rats
Receptors, Calcitonin Gene-Related Peptide--metabolism
Respiratory Mucosa--drug effects