MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.

Ai, Jing

MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Feb 2013 - 3989-4001 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.1997-12.2013 doi


Aged
Aged, 80 and over
Amyloid Precursor Protein Secretases--genetics
Amyloid beta-Peptides--blood
Amyloid beta-Protein Precursor--genetics
Analysis of Variance
Animals
Animals, Newborn
Aspartic Acid Endopeptidases--genetics
Carotid Artery Diseases--complications
Cells, Cultured
Cerebral Cortex--cytology
Dementia--etiology
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Regulation--drug effects
Hippocampus--cytology
Humans
Immunoprecipitation
Lipopolysaccharides--pharmacology
Male
Maze Learning--drug effects
MicroRNAs--biosynthesis
Neurons--drug effects
Neuroprotective Agents--metabolism
Oligonucleotides, Antisense--pharmacology
Peptide Fragments--metabolism
Protein Serine-Threonine Kinases--genetics
RNA, Messenger--metabolism
Rats
Rats, Sprague-Dawley
Transfection
NF-kappaB-Inducing Kinase